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Unlike MVD measurement, DCE-MRI can provide information on whole tumor volumes and not only on focal regions, which is more informative because tumor vasculature is heterogeneously distributed throughout the tumor[12]. Using a pharmacokinetic analysis, DCE-MRI can yield two parameters: the tumor transfer coefficient (Ktrans) and the extravascular extracellular volume (ve), which can be used to evaluate tumor microvessel perfusion and the permeability of the tumor vasculature[13].. Adequate nutritional support of severe primary protein energy malnutrition (PEM) is indispensable for achieving normal immune response. However, an ideal dietetic criterion has not yet been established or accepted by the majority of health professionals caring for malnourished infants. Our objective was to demonstrate improvement in immune response in infants with PEM who received starting infant formula with nucleotides.

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