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ConclusionsOur results show that ATOR protects the liver from I/R injury.. The guidelines recommend the use of interferon-gamma release assays (IGRAs) for screening – tests developed as an alternative method to the TST. These assays detect either the frequency of activated specific T-cells releasing IFN–γ isolated from peripheral mononuclear cells, or the amount of IFN–γ released in response to M. tuberculosis proteins. These antigens are encoded by mycobacterium-specific genes, which are not shared with the BCG vaccine strains or non-tuberculosis mycobacterium and are believed to be more specific than the TST7. Because of these characteristics, false-positive reactions due to BCG vaccination and atypical mycobacterium are limited, but IFN–γ is known to be a crucial mediator in the cytokine cascade of psoriasis. Considerable amounts of IFN–γ-positive cells were found in psoriatic skin; also the expression of interleukin–12 is increased in psoriatic lesions8. Psoriasis was also associated with elevated serum levels of IFN–γ9, which raises questions about the specificity of IGRAs in psoriatic patients.
The guidelines recommend the use of interferon-gamma release assays (IGRAs) for screening – tests developed as an alternative method to the TST. These assays detect either the frequency of activated specific T-cells releasing IFN–γ isolated from peripheral mononuclear cells, or the amount of IFN–γ released in response to M. tuberculosis proteins. These antigens are encoded by mycobacterium-specific genes, which are not shared with the BCG vaccine strains or non-tuberculosis mycobacterium and are believed to be more specific than the TST7. Because of these characteristics, false-positive reactions due to BCG vaccination and atypical mycobacterium are limited, but IFN–γ is known to be a crucial mediator in the cytokine cascade of psoriasis. Considerable amounts of IFN–γ-positive cells were found in psoriatic skin; also the expression of interleukin–12 is increased in psoriatic lesions8. Psoriasis was also associated with elevated serum levels of IFN–γ9, which raises questions about the specificity of IGRAs in psoriatic patients.. Mn is an element essential for health in trace amounts, but toxic at higher levels. There are a few reports in the literature examining the effects of excess oral exposure of humans to Mn. The urine of CAD patients also shows higher Mn concentrations than that of healthy controls (24). In atherosclerotic subjects, the Mn content of the heart and aorta of atherosclerotic subjects is lower and plasma levels are higher than in healthy controls (25-27). This increase is so rapid and specific that it may be used as a diagnostic indicator of a recent MI. In the present study however, Mn concentrations were not significantly increased in patients with CAD..
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